Department of Basic Sciences: Recent submissions
Now showing items 61-70 of 70
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Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation
(2016-10)The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential ... -
[3+2] Cycloaddition-based one-pot synthesis of 3,9-diazabicyclo[4.2.1]nonane-containing scaffold
(2017-01)Three-component [3+2] cycloaddition followed by reduction and lactamization has been developed as a one-pot methodology for diastereoselective synthesis of 3,9-diazabicyclo[4.2.1]nonane-containing scaffold. -
One-pot and catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates†
(2017)A method for the catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates is develo ped through a one-pot synthesis involving denitrogenation of azide, benzisoxazole formation, aza-Diels– Alder ... -
Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors
(2018)The simultaneous inhibition of polo-like kinase 1 (PLK1) and BRD4 bromodomain by a single molecule could lead to the development of an effective therapeutic strategy for a variety of diseases in which PLK1 and BRD4 are ... -
[3 + 2] Cycloaddition and Cascade Radical Reactions for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones
(2019-04-01)A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of ... -
Development of Dimethylisoxazole-Attached Imidazo[1,2‑a]pyridines as Potent and Selective CBP/P300 Inhibitors
(2021)The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned from targeting bromodo main extraterminal domain (BET) proteins into targeting non-BET bromodomains. The two most relevant non-BET ... -
Sequential (3 + 2) cycloaddition and (5 + n) annulation for modular synthesis of dihydrobenzoxazines, tetrahydrobenzoxazepines and tetrahydrobenzoxazocines†
(2018-06)A two-step method for the (3 + 2) cycloaddition of azomethine ylides followed by a double SN2 substi tution-based (5 + n) annulation is introduced for the modular synthesis of dihydrobenzoxazine, tetra hydrobenzoxazepine ... -
Analysis of Effect of Inclined Magnetic Field on MHD Boundary Layer Flow over a Porous Exponentially Stretching Sheet Subject to Thermal Radiation
(2021-10-30)MHD flow has a wide range of industrial applications such as MHD propulsion for space exploration, cooling of nuclear reactors, electronic packages, microelectronic devices, and many more. Due to this, a study on the ... -
Efficacy of Mangrove (Rhizophora Mucronata) Roots Powder in Adsorption of Lead (II) Ions from Aqueous Solutions: Equilibrium and Kinetics Studies
(2016-08)The removal of Pb (II) ions by adsorption onto mangrove roots adsorbent was investigated in this present paper. The removal of lead ions from aqueous solutions was investigated in batch mode which involved the study of ... -
Equilibrium and Kinetics Studies for the Adsorption of Aqueous Cu (II) ions onto Mangroves Biomass
(2013)In this study, adsorption of copper from aqueous solutions was investigated using mangrove biomass from the Kenyan Coast. The efficacy of mangrove biomass on the removal of copper (II) ions from aqueous solutions was ...